GHK-CU

GHK-Cu 50mg

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper-binding tripeptide complex consisting of glycine, histidine, and lysine bound to a copper(II) ion. Originally identified by Loren Pickart in human plasma, GHK-Cu has been the subject of extensive cellular biology and biochemical research literature for over five decades, with research contexts examining tissue biology, cellular signaling pathways, copper-binding peptide chemistry, and extracellular matrix research.

Each vial contains 50mg of lyophilized GHK-Cu in a sealed 3mL glass vial, verified through Ancestral Bio’s three-tier quality protocol: 7x independent third-party analytical testing, 4-vial batch conformity verification, and comprehensive heavy metal screening.

Product Specifications

• Compound: GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper)
• Class: Naturally occurring copper-binding tripeptide complex
• Sequence: Gly-His-Lys
• Molecular Weight: ~340 Da (tripeptide); ~403 Da (copper complex)
• Form: Lyophilized powder
• Vial Size: 50mg in 3mL glass vial
• Purity: 99%+ verified by HPLC and mass spectrometry (See COAs)

Research Background

GHK-Cu has been investigated in research literature across several scientific contexts:

• Tissue biology research — investigations into peptide-copper complex effects on cellular signaling pathways in tissue models
• Extracellular matrix research — studies examining cellular responses involving collagen synthesis pathways and matrix protein regulation in cell culture systems
• Copper-binding peptide chemistry — analytical chemistry research on GHK’s selective copper binding properties and the cellular biology of copper homeostasis
• Cellular signaling pathway research — investigations into GHK-Cu’s interactions with cellular receptor systems and downstream signaling cascades
• Gene expression research — studies examining GHK-Cu’s effects on cellular gene expression patterns in research models
• Comparative peptide research — analytical studies positioning GHK-Cu alongside other naturally occurring copper-binding peptides in cellular research contexts

GHK-Cu is historically significant as one of the most extensively studied naturally occurring copper-binding peptides, originally identified through isolation from human plasma. The compound has been characterized across thousands of peer-reviewed publications examining its role in cellular biology. Foundational research is available through PubMed (pubmed.ncbi.nlm.nih.gov) and the National Institutes of Health’s PMC database (pmc.ncbi.nlm.nih.gov), where researchers can access peer-reviewed studies on GHK-Cu cellular biology and copper-binding peptide research.

Analytical Verification

Every batch undergoes AncestralBio’s comprehensive analytical protocol:

• High-Performance Liquid Chromatography (HPLC) for purity quantification
• Mass Spectrometry (MS) for molecular weight and identity confirmation
• 14-day sterility testing
• Endotoxin analysis
• 4-vial batch conformity verification — statistically robust consistency testing across each production batch, exceeding the industry-standard single-vial sampling approach
• Heavy metal screening for lead, arsenic, cadmium, mercury, and additional trace metals
• Container and seal integrity verification

Certificates of Analysis (COAs) accompany every order, documenting full testing results across all verification protocols.

Reconstitution and Storage

• Lyophilized storage: Cool, dry location away from direct light; -20°C for long-term stability
• Post-reconstitution: Refrigerate at 2-8°C, protect from light
• Reconstituted use window: 30 days for optimal research integrity
• Avoid: Repeated freeze-thaw cycles to preserve compound stability and structural integrity

Quality Standards

Ancestral Bio maintains a rigorous quality control framework across all research compounds. Our multi-layered testing protocol provides researchers with verified, high-purity reference materials supported by complete analytical documentation.

• 7x independent third-party testing per batch
• 4-vial batch conformity verification
• Heavy metal screening for trace contaminant analysis
• cGMP-compliant manufacturing
• Full analytical traceability

Terms of Sale

This product is supplied for in vitro laboratory research only and has not been evaluated by the U.S. Food and Drug Administration. By purchasing, the buyer confirms they are 21 or older, a qualified research professional or institution, and will not use this material for human consumption, veterinary use, or any in vivo application. Ancestral Bio assumes no liability for misuse or off-label application.

About AncestralBio

US-based research compound supplier specializing in high-purity reference materials for laboratory applications. Every batch undergoes our three-tier quality protocol: 7x independent third-party analytical verification, 4-vial batch conformity testing, and comprehensive heavy metal screening — manufactured in cGMP-compliant facilities.